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BMJ Journals

Online First

June 12, 2024

Correction
Correction: Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer
Free

doi: 10.1136/gutjnl-2017-314408corr1
Letter
Porcine-derived pancreatic enzyme replacement therapy linking to chronic hepatitis E: broad implications

Jiahua Zhou, Kuan Liu, Qiuwei Pan

doi: 10.1136/gutjnl-2024-332975

June 11, 2024

Recent advances in basic science
Nuclear receptors: pathophysiological mechanisms and drug targets in liver disease

Vanessa Dubois, Philippe Lefebvre, Bart Staels, Jerome Eeckhoute

doi: 10.1136/gutjnl-2023-331741

June 10, 2024

Inflammatory bowel disease
Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease

Thomas W Dennison, Rachel D Edgar, Felicity Payne, Komal M Nayak, Alexander D. B. Ross, Aurelie Cenier, Claire Glemas, Federica Giachero, April R Foster, Rebecca Harris, Judith Kraiczy, Camilla Salvestrini, Georgia Stavrou, Franco Torrente, Kimberley Brook, Claire Trayers, Rasa Elmentaite, Gehad Youssef, Bálint Tél, Douglas James Winton, Nefeli Skoufou-Papoutsaki, Sam Adler, Philip Bufler, Aline Azabdaftari, Andreas Jenke, Natasha G, Natasha Thomas, Erasmo Miele, Abdulrahman Al-Mohammad, Greta Guarda, Subra Kugathasan, Suresh Venkateswaran, Menna R Clatworthy, Tomas Castro-Dopico, Ondrej Suchanek, Caterina Strisciuglio, Marco Gasparetto, Seokjun Lee, Xingze Xu, Erica Bello, Namshik Han, Daniel R. Zerbino, Sarah A Teichmann, Josquin Nys, Robert Heuschkel, Francesca Perrone, Matthias Zilbauer

doi: 10.1136/gutjnl-2024-332043
GI cancer
PARP-1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma

Friederike L Keggenhoff, Darko Castven, Diana Becker, Stojan Stojkovic, Jovana Castven, Carolin Zimpel, Beate K Straub, Tiemo Gerber, Harald Langer, Patricia Hähnel, Thomas Kindler, Jörg Fahrer, Colm J O'Rourke, Ursula Ehmer, Anna Saborowski, Lichun Ma, Xin Wei Wang, Timo Gaiser, Matthias S Matter, Christian Sina, Stefanie Derer, Ju-Seog Lee, Stephanie Roessler, Bernd Kaina, Jesper B Andersen, Peter R Galle, Jens U Marquardt

doi: 10.1136/gutjnl-2023-331237
Editor’s quiz: GI snapshot
GI snapshot: arrhythmia, dysphagia and weight loss in a 71-year-old man

Martina De Siena, Loredana Gualtieri, Simone Varca, Maria Valeria Matteo, Valerio Pontecorvi, Vincenzo Bove, Cristiano Spada, Ivo Boškoski

doi: 10.1136/gutjnl-2023-331813
Gut microbiota
Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production

doi: 10.1136/gutjnl-2024-331880

June 08, 2024

Recent advances in basic science
Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia

Marietta Iacucci, Giovanni Santacroce, Snehali Majumder, Jennifer Morael, Irene Zammarchi, Yasuharu Maeda, David Ryan, Antonio Di Sabatino, Maria Rescigno, Maria R Aburto, John F Cryan, Subrata Ghosh

doi: 10.1136/gutjnl-2023-331579

June 05, 2024

Hepatology
Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma

Ao Chen, Vanilla Xin Zhang, Qingyang Zhang, Karen Man-Fong Sze, Lu Tian, Hongyang Huang, Xia Wang, Eva Lee, Jingyi Lu, Xueying Lyu, Man-Fong Joyce Lee, Chun Ming Wong, Daniel Wai-Hung Ho, Irene Oi-Lin Ng

doi: 10.1136/gutjnl-2024-331903
Intestinal inflammation
Protective function of sclerosing cholangitis on IBD

Tanja Bedke, Friederike Stumme, Miriam Tomczak, Babett Steglich, Rongrong Jia, Simon Bohmann, Agnes Wittek, Jan Kempski, Emilia Göke, Marius Böttcher, Dominik Reher, Anissa Franke, Maximilian Lennartz, Till Clauditz, Guido Sauter, Thorben Fründt, Sören Weidemann, Gisa Tiegs, Christoph Schramm, Nicola Gagliani, Penelope Pelczar, Samuel Huber

doi: 10.1136/gutjnl-2023-330856
Colon
Risk of colorectal neoplasia after removal of conventional adenomas and serrated polyps: a comprehensive evaluation of risk factors and surveillance use

Georgios Polychronidis, Ming-Ming He, Mathew Vithayathil, Markus D Knudsen, Kai Wang, Mingyang Song

doi: 10.1136/gutjnl-2023-331729
Hepatology
Effectiveness of mailed outreach and patient navigation to promote HCC screening process completion: a multicentre pragmatic randomised clinical trial

Amit G Singal, Manasa Narasimman, Darine Daher, Sruthi Yekkaluri, Yan Liu, MinJae Lee, Vanessa Cerda, Aisha Khan, Karim Seif El Dahan, Jennifer Kramer, Purva Gopal, Caitlin Murphy, Ruben Hernaez

doi: 10.1136/gutjnl-2024-332508

June 04, 2024

GI cancer
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer

Anna Brichkina, Miriam Ems, Roman Suezov, Rajeev Singh, Veronika Lutz, Felix S R Picard, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Michael Daude, Wibke E Diederich, Florian Finkernagel, Ho-Ryun Chung, Detlef K Bartsch, Katrin Roth, Corinna Keber, Carsten Denkert, Magdalena Huber, Thomas M Gress, Matthias Lauth

doi: 10.1136/gutjnl-2023-331854
Recent advances in clinical practice
Acute severe ulcerative colitis trials: the past, the present and the future

Sailish Honap, Vipul Jairath, Bruce E Sands, Parambir S Dulai, Silvio Danese, Laurent Peyrin-Biroulet

doi: 10.1136/gutjnl-2024-332489

May 31, 2024

Commentary
Glowing insights: tracking vedolizumab in the mucosa of patients with IBD via molecular endoscopy

Raja Atreya

doi: 10.1136/gutjnl-2024-332503
Commentary
Potential risk of porcine-derived pancreatic enzyme medication for the cross-species transmission of hepatitis E virus

Nicola Frericks, Volker Kinast, Eike Steinmann

doi: 10.1136/gutjnl-2024-332577
Pancreas
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2

Markus Vogt, Nevenka Dudvarski Stankovic, Yiliam Cruz Garcia, Julia Hofstetter, Katharina Schneider, Filiz Kuybu, Theresa Hauck, Bikash Adhikari, Anton Hamann, Yamila Rocca, Lara Grysczyk, Benedikt Martin, Anneli Gebhardt-Wolf, Armin Wiegering, Markus Diefenbacher, Georg Gasteiger, Stefan Knapp, Dieter Saur, Martin Eilers, Mathias Rosenfeldt, Florian Erhard, Seychelle M Vos, Elmar Wolf

doi: 10.1136/gutjnl-2023-331519

May 30, 2024

Neurogastroenterology
Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue

Benjamin Jevans, Fay Cooper, Yuliia Fatieieva, Antigoni Gogolou, Yi-Ning Kang, Restuadi Restuadi, Dale Moulding, Pieter Vanden Berghe, Igor Adameyko, Nikhil Thapar, Peter W Andrews, Paolo De Coppi, Anestis Tsakiridis, Conor J McCann

doi: 10.1136/gutjnl-2023-331532

May 23, 2024

Hepatology
Association between primary hypothyroidism and metabolic dysfunction-associated steatotic liver disease: an updated meta-analysis

Alessandro Mantovani, Alessandro Csermely, Josh Bilson, Niccolò Borella, Scoccia Enrico, Barbara Pecoraro, Emigela Shtembari, Riccardo Morandin, Stergios A Polyzos, Luca Valenti, Herbert Tilg, Christopher D Byrne, Giovanni Targher

doi: 10.1136/gutjnl-2024-332491
Recent advances in clinical practice
‘Unusual’ HCV genotype subtypes: origin, distribution, sensitivity to direct-acting antiviral drugs and behaviour on antiviral treatment and retreatment

Erwan Vo-Quang, Jean-Michel Pawlotsky

doi: 10.1136/gutjnl-2024-332177

May 22, 2024

Hepatology
Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis

Mrigya Babuta, Caroline Morel, Marcelle de Carvalho Ribeiro, Charles Calenda, Martí Ortega-Ribera, Prashanth Thevkar Nagesh, Christopher Copeland, Yuan Zhuang, Yanbo Wang, Yeonhee Cho, Radhika Joshi, Viliam Brezani, Danielle Hawryluk, Aditi Ashish Datta, Jeeval Mehta, Imad Nasser, Gyongyi Szabo

doi: 10.1136/gutjnl-2023-331447
Recent advances in clinical practice
Heavy arch: from inflammatory bowel diseases to metabolic disorders

Timon E Adolph, Moritz Meyer, Almina Jukic, Herbert Tilg

doi: 10.1136/gutjnl-2024-331914
Recent advances in basic science
Intravital imaging: dynamic insights into liver immunity in health and disease

Yuting Wang, Felix Heymann, Moritz Peiseler

doi: 10.1136/gutjnl-2023-331739

May 16, 2024

Letter
Intron-mediated enhancement of SPINK1 expression for pancreatitis therapy

Gergő Berke, Miklós Sahin-Tóth

doi: 10.1136/gutjnl-2024-332818
Commentary
Eosinophils: a novel therapeutic target to promote liver regeneration in acute liver injury?

Hong-Min Ni, Amaya Lopez-Pascual

doi: 10.1136/gutjnl-2024-332692
Pancreas
The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells

Juan Carlos López-Gil, Susana García-Silva, Laura Ruiz-Cañas, Diego Navarro, Adrián Palencia-Campos, Antonio Giráldez-Trujillo, Julie Earl, Jorge Dorado, Gonzalo Gómez-López, Ana Monfort-Vengut, Sonia Alcalá, Matthias M Gaida, Sandra García-Mulero, Pablo Cabezas-Sáinz, Sandra Batres-Ramos, Emma Barreto, Patricia Sánchez-Tomero, Mireia Vallespinós, Leah Ambler, Meng-Lay Lin, Alexandra Aicher, Ana García García de Paredes, Carolina de la Pinta, Alfonso Sanjuanbenito, Ignacio Ruz-Caracuel, Mercedes Rodríguez-Garrote, Carmen Guerra, Alfredo Carrato, Guillermo de Cárcer, Laura Sánchez, César Nombela-Arrieta, Elisa Espinet, Víctor Javier Sanchez-Arevalo Lobo, Christopher Heeschen, Bruno Sainz

doi: 10.1136/gutjnl-2023-330995

May 15, 2024

Letter
Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer

Shaida Ouladan, Elias Orouji

doi: 10.1136/gutjnl-2024-332325
Endoscopy
Diagnostic yield from symptomatic gastroscopy in the UK: British Society of Gastroenterology analysis using data from the National Endoscopy Database

David Robert Beaton, Linda Sharp, Liya Lu, Nigel J Trudgill, Mo Thoufeeq, Brian D Nicholson, Peter Rogers, James Docherty, Anna Jenkins, Allan John Morris, Thomas Rösch, Matthew D Rutter

doi: 10.1136/gutjnl-2024-332071

May 13, 2024

GI cancer
Targeting squalene epoxidase restores anti-PD-1 efficacy in metabolic dysfunction-associated steatohepatitis-induced hepatocellular carcinoma

Jun Wen, Xiang Zhang, Chi Chun Wong, Yating Zhang, Yasi Pan, Yunfei Zhou, Alvin Ho-Kwan Cheung, Yali Liu, Fenfen Ji, Xing Kang, Dabin Liu, Jun Yu

doi: 10.1136/gutjnl-2023-331117
Gut microbiota
Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice

Paola Paone, Dimitris Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Valentina Borlandelli, Francesco Suriano, Malin E V Johansson, Anthony Puel, Caroline Bouzin, Nathalie M Delzenne, Anne Salonen, Nathalie Juge, Bogdan I Florea, Giulio G Muccioli, Herman Overkleeft, Matthias Van Hul, Patrice D Cani

doi: 10.1136/gutjnl-2023-330301

May 09, 2024

Hepatology
Novel IL-4/HB-EGF-dependent crosstalk between eosinophils and macrophages controls liver regeneration after ischaemia and reperfusion injury

Yang Yang, Long Xu, Constance Atkins, Lily Kuhlman, Jie Zhao, Jong-Min Jeong, Yankai Wen, Nicolas Moreno, Kang Ho Kim, Yu A An, Fenfen Wang, Steve Bynon, Vincenzo Villani, Bin Gao, Frank Brombacher, Raymond Harris, Holger K Eltzschig, Elizabeth Jacobsen, Cynthia Ju

doi: 10.1136/gutjnl-2024-332033
Gut microbiota
Landscape of the gut mycobiome dynamics during pregnancy and its relationship with host metabolism and pregnancy health

Yuanqing Fu, Wanglong Gou, Ping Wu, Yuwei Lai, Xinxiu Liang, Ke Zhang, Menglei Shuai, Jun Tang, Zelei Miao, Jieteng Chen, Jiaying Yuan, Bin Zhao, Yunhaonan Yang, Xiaojuan Liu, Yayi Hu, An Pan, Xiong-Fei Pan, Ju-Sheng Zheng

doi: 10.1136/gutjnl-2024-332260
Editor’s quiz: GI snapshot
Diagnostic dilemma: sudden onset of multiple skin lesions in a patient with intestinal disease

Cong Dai, Yu-hong Huang

doi: 10.1136/gutjnl-2024-332717

May 06, 2024

GI cancer
Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer

Huisi He, Shuzhen Chen, Yong Yu, Zhecai Fan, Youwen Qian, Yaping Dong, Yuting Song, Caiming Zhong, Xiaojuan Sun, Qiqi Cao, Shiyao Li, Weihan Huang, Wenxin Li, Mingzhu Zhuang, Jinxian Yang, Xianming Wang, Jiaqian Wang, Dongfang Wu, Hongyang Wang, Wen Wen

doi: 10.1136/gutjnl-2023-331773
Editor’s quiz: GI snapshot
Perplexing case of abdominal pain with eosinophilia and fasciitis

Robert Sean O'Neill, Logan Gardner, Anthony Kelleher, Roger Pamphlett, Laila Girgis, Alina Stoita

doi: 10.1136/gutjnl-2024-332580

May 02, 2024

Hepatology
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism

Armando Andres Roca Suarez, Marie-Laure Plissonnier, Xavier Grand, Maud Michelet, Guillaume Giraud, Maria Saez-Palma, Anaëlle Dubois, Sarah Heintz, Audrey Diederichs, Nicolaas Van Renne, Thomas Vanwolleghem, Stephane Daffis, Li Li, Nikita Kolhatkar, Yao-Chun Hsu, Jeffrey J Wallin, Audrey H Lau, Simon P Fletcher, Michel Rivoire, Massimo Levrero, Barbara Testoni, Fabien Zoulim

doi: 10.1136/gutjnl-2023-331396
Letter
Concerns about instrumental variable selection for biological effect versus uptake of proton pump inhibitors in Mendelian randomisation analysis

Shuai Yuan, Susanna C Larsson, Dipender Gill, Stephen Burgess

doi: 10.1136/gutjnl-2024-332280

April 29, 2024

Inflammatory bowel disease
Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis

Lena Erkert, Reyes Gamez-Belmonte, Melanie Kabisch, Lena Schödel, Jay V Patankar, Miguel Gonzalez-Acera, Mousumi Mahapatro, Li-Li Bao, Christina Plattner, Anja A Kühl, Jie Shen, Lutgarde Serneels, Bart De Strooper, TRR241 IBDome Consortium, Markus F Neurath, Stefan Wirtz, Christoph Becker

doi: 10.1136/gutjnl-2023-331622
Guideline
British Society of Gastroenterology guidelines for the management of hepatocellular carcinoma in adults

Abid Suddle, Helen Reeves, Richard Hubner, Aileen Marshall, Ian Rowe, Dina Tiniakos, Stefan Hubscher, Mark Callaway, Dinesh Sharma, Teik Choon See, Maria Hawkins, Suzanne Ford-Dunn, Sarah Selemani, Tim Meyer

doi: 10.1136/gutjnl-2023-331695

April 26, 2024

Letter
Inappropriate use of proton pump inhibitors in clinical practice globally: a systematic review and meta-analysis

Amit K Dutta, Vishal Sharma, Abhinav Jain, Anshuman Elhence, Manas K Panigrahi, Srikant Mohta, Richard Kirubakaran, Mathew Philip, Mahesh Goenka, Shobna Bhatia, Usha Dutta, D Nageshwar Reddy, Rakesh Kochhar, Govind K Makharia

doi: 10.1136/gutjnl-2024-332154
Pancreas
Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

Francesca Lupo, Francesco Pezzini, Davide Pasini, Elena Fiorini, Annalisa Adamo, Lisa Veghini, Michele Bevere, Cristina Frusteri, Pietro Delfino, Sabrina D'agosto, Silvia Andreani, Geny Piro, Antonia Malinova, Tian Wang, Francesco De Sanctis, Rita Teresa Lawlor, Chang-il Hwang, Carmine Carbone, Ivano Amelio, Peter Bailey, Vincenzo Bronte, David Tuveson, Aldo Scarpa, Stefano Ugel, Vincenzo Corbo

doi: 10.1136/gutjnl-2023-329807

April 25, 2024

Commentary
Targeting hepatic stellate cells to combat liver fibrosis: where do we stand?

Katja Breitkopf-Heinlein, Maria Luz Martinez-Chantar

doi: 10.1136/gutjnl-2023-331785
Editor’s quiz: GI snapshot
Underdiagnosed cause of gastrointestinal bleeding

Xin-Yue Ma, Yun Cui, Jing-Yuan Fang, Danfeng Sun

doi: 10.1136/gutjnl-2024-332632

April 23, 2024

Pancreas
Impact of age, comorbidities and relevant changes on surveillance strategy of intraductal papillary mucinous neoplasms: a competing risk analysis

Stefano Crippa, Giovanni Marchegiani, Giulio Belfiori, Paola Vittoria Maria Rancoita, Tommaso Pollini, Anna Burelli, Laura Apadula, Maria Giovanna Scarale, Davide Socci, Marco Biancotto, Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso, Roberto Salvia, Massimo Falconi

doi: 10.1136/gutjnl-2023-329961

April 19, 2024

Oesophagus
Hypoxia-inducible factor-1α mediates reflux-induced epithelial-mesenchymal plasticity in Barrett’s oesophagus patients

Qiuyang Zhang, Kerry B Dunbar, Robert D Odze, Agoston T Agoston, Xuan Wang, Tianhong Su, Anh D Nguyen, Xi Zhang, Stuart Jon Spechler, Rhonda F Souza

doi: 10.1136/gutjnl-2023-331467

April 18, 2024

Commentary
Mast cells and histamine in cholangiocarcinoma: exploring overlooked avenues for enhanced patient management

Luca Fabris, Jonathan Pol

doi: 10.1136/gutjnl-2024-332288

April 15, 2024

GI cancer
Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer

Feifei Zhang, Varun Sahu, Ke Peng, Yichen Wang, Tianxia Li, Pratyusha Bala, Daulet Aitymbayev, Pranshu Sahgal, Antje Schaefer, Channing J Der, Sandra Ryeom, Sam Yoon, Nilay Sethi, Adam J Bass, Haisheng Zhang

doi: 10.1136/gutjnl-2023-329686
Pancreas
Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients

Christina S Thornton, Barbara J Waddell, Stephen E Congly, Julianna Svishchuk, Ranjani Somayaji, Linda Fatovich, Debra Isaac, Karen Doucette, Kevin Fonseca, Steven J Drews, Jamie Borlang, Carla Osiowy, Michael D Parkins

doi: 10.1136/gutjnl-2023-330602

April 12, 2024

Letter
EUS-guided gallbladder drainage in acute cholecystitis: response to letter to the editor

Ji Young Bang, Juan Pablo Arnoletti, Andrew Wagner, Shyam Varadarajulu

doi: 10.1136/gutjnl-2024-332342

April 10, 2024

Probiotics
Lactococcus lactis HkyuLL 10 suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase

Anthony Chin Yang Su, Xiao Ding, Harry Cheuk Hay Lau, Xing Kang, Qing Li, Xueliang Wang, Yali Liu, Lanping Jiang, Yinghong Lu, Weixin Liu, Yanqiang Ding, Alvin Ho-Kwan Cheung, Ka Fai To, Jun Yu

doi: 10.1136/gutjnl-2023-330835

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